Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes

LJ Collin; KL Cushing-Haugen; KL Terry; EL Goode; AH Wu; HR Harris; N Sasamoto; DW Cramer; F Modugno; E Elishaev; Z Fu; KB Moysich; PA Fasching; CL Pearce; U Menon; A Gentry-Maharaj; SA Gayther; N Wentzensen; MT Goodman; J George; A Talhouk; MS Anglesio; SJ Ramus; DDL Bowtell; SS Tworoger; JM Schildkraut; PM Webb; JA Doherty

Journal article

Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes

LJ Collin, KL Cushing-Haugen, KL Terry, EL Goode, AH Wu, HR Harris, N Sasamoto, DW Cramer, F Modugno, E Elishaev, Z Fu, KB Moysich, PA Fasching, CL Pearce, U Menon, A Gentry-Maharaj, SA Gayther, N Wentzensen, MT Goodman, J George Show all

Cancer Epidemiology Biomarkers and Prevention | Published : 2025

DOI: 10.1158/1055-9965.EPI-24-1143

Download PDF

Abstract

Background: Ovarian high-grade serous carcinomas (HGSC) comprise four distinct molecular subtypes based on mRNA expression patterns, with differential survival. Understanding risk factor associations is important to elucidate the etiology of HGSC. We investigated associations between different epidemiologic risk factors and HGSC molecular subtypes. Methods: We pooled data from 11 case-control studies with epidemiologic and tumor gene expression data from custom NanoString CodeSets developed through a collaboration within the Ovarian Tumor Tissue Analysis consortium. The PrOTYPEvalidated NanoString-based 55-gene classifier was used to assign HGSC gene expression subtypes. We examined associat..

View full abstract

University of Melbourne Researchers

David Bowtell Author

Related Projects (5)

IMPROVING OUTCOMES FOR WOMEN WITH EPITHELIAL OVARIAN CANCER

THE MOLECULAR BIOLOGY OF HUMAN OVARIAN CANCER

The Fellowship would support Professor Bowtell, one of the world’s leading ovarian cancer researchers. His work focuses on clinical problems..

Molecular Epidemiology of Ovarian Research Institute

PUBLIC ABSTRACT A major obstacle to preventive strategies for ovarian cancer is the lack of recognized modifiable risk factors. Age, a pos..

Molecular Epidemiology of Ovarian Cancer: The Australian Ovarian Cancer Study National Clinical Follow-Up Core

Ovarian cancer is the seventh most common cancer in Australian women and fifth most common cause of cancer death, with approximately 1200 ne..

AUSTRALIAN OVARIAN CANCER STUDY (AOCS): A MULTIDISCIPLINARY OVARIAN CANCER RESOURCE FOR THE GENOMICS ERA

Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level..

Grants

Awarded by Michael Smith Health Research BC

Citation metrics

1Dimensions

Keywords

Clinical Research

Women'S Health

32 Biomedical and Clinical Sciences

3211 Oncology and Carcinogenesis

2.1 Biological and Endogenous Factors

Prevention

Genetics

3 Good Health and Well Being

Cancer

Ovarian Cancer

Rare Diseases